Half
of all new cancers are skin cancers. In fact, they're more common
than cancers of any other organ. Over 1.3 million cases of basal cell
and squamous cell skin cancer are expected to be diagnosed this year.1
Sobering isn't it? But now a powerful form of an old standby offers
new hope.
The antioxidant advantage
Antioxidants
like vitamin C and E have become very popular in skin products and
for good reason. There's a wealth of research documenting their value
in protecting the skin from sun damage.
Most
skin cancer is caused by overexposure to the sun. The ultraviolet
(UV) radiation generates an excessive number of superoxide radicals
in exposed skin cells. These highly reactive molecules can, among
other things, cause serious damage to your DNA. As a result of this,
skin cells may begin to reproduce uncontrollably, leading to benign,
precancerous, or malignant lesions on the skin.2 In short, sun exposure
can lead to skin weathering,3 abnormal growths, and in serious cases,
skin cancer.4
Antioxidants counteract this effect by coupling with the free radicals
before they can harm the DNA. The effectiveness of antioxidants in
protecting the skin against sun damage has been well documented. A
double-blind placebo study held at the University of Munich found
that combined antioxidants (vitamins C and E in the study) reduce
the sunburn reaction stopping the skin damage before it degenerates
to something more serious.5
The
following year, University of Leiden researchers demonstrated that
topically applied antioxidants can be used to prevent UV rays from
damaging epidermal layers. (In this study, the experiments were conducted
on mice.)6
In
a study carried out specifically on the antioxidant qualities of vitamin
E, researchers concluded that it's an effective sunscreen and prevents
the formation of DNA lesions that lead to skin cancer.7
Natural compound combats aging and cancer
One
of our panelists, Dr. Randall Wilkinson, has developed a skin cream
to help you win the war against skin cancer and aging. It's a combination
of several elemnts, all of which add up to one of the most powerful
skin-care products on the market, both for its disease-fighting capabilities
and for its ability to restore a youthful appearance to the skin.
Trienelle
Daily Renewal CrËme is designed to address both the issue of cellular
damage that can lead to skin malignancies as well as the more cosmetic
issue of premature aging and skin weathering. In doing so, it uses
a very unique and scientifically supported combination of natural
ingredients.
Trienelle harnesses the proven power of tocotrienols
While
vitamin E is helpful in protecting the skin from UV damage, not all
vitamin E is created equal. The key is to find the most effective
form to carry out this all-important task. That's where tocotrienols
come in. As we reported in last month's Memebers Alert (as well as
the December 1997 issue), there are two primary forms of vitamin E:
tocotrienol and the more common alpha-tocopherol. While alpha-tercopherols
are used in face creams and the majority of nutritional supplements
on the market, tocotrienols are actually far more potent, up to 60
times more effective.8
Trienelle includes both tocotrienols and mixed tocopherols, to take
advantage of the full range of both forms of vitamin E.
Recent
studies have verified this, concluding that the physiological activities
of tocotrienols make them superior to alpha-tocopherols and that its
role in cancer prevention may have "significant clinical implications."9
Tocotrienols
offers other distinct advantages over alpha-tocopherols and other
antioxidant nutrients used in skin-care products. They're better absorbed
and distributed in the superficial and deep skin layers.10 Unlike
alpha-tocopherol, which is quickly depleted by UV exposure, tocotrienols
remain in the skin at greater concentrations and even help to preserve
the levels of tocopherols in the skin. Tocotrienols, when applied
to the skin, also help to retain vitamin E, even after UV exposure.11
And,
in addition to its antioxidant capacity, tocotrienols have another
important role in derailing the cancer process at the cellular level.
As described in the September 1998 Member's Alert, tocotrienols also
regulate a key biochemical supply necessary for cell proliferation.
To put it simply, tocotrienols help short-circuit the excess spreading
of cells, even when DNA damage has occurred.
Recent
studies have verified that the physiological activities of tocotrienols
make them superior to alpha tocopherols and that its role in cancer
preventionmay have "significant clinical implications."
Trienelle
includes both tocotrienols and mixed tocopherols, to take advantage
of the full range of both forms of vitamin E, incorporating a particularly
potent concentration of tocotrienols (extracted from rice bran and
palm oil) for maximum benefit. Trienelle is the only skin-care product
that uses tocotrienols, while alpha-tocopherol crËmes are readily
available.
A new technology for skin care
Trienelle
uses a newly developed technology to deliver the maximum benefit to
your skin. It's called the TololurTM Skin Nutrition Complex, and it
features an advanced liposomal delivery system. Liposomes are tiny
drop like particles 300 times smaller than cells, Encased by fat-soluble
membranes made from the same material as actual cells, liposomes penetrate
quickly and deeply through the waterproof outer layer of the skin.
When the liposomes come into contact with the cells of the dermis,
the nutrients contained inside are transferred via osmosis into the
living cells.
Each
Tocolur liposome contains both tocotrienols and tocopherols, In addition,
the formulators have included applephenone, a recently discovered
super-potent antioxidant. Extracted from green apples, applephenone
also protects cells against carcinogens and is a natural antihistamine
(helping to block allergic reactions like hives).
Trienelle offers complete skin protection
Dr.
Wilkinson's goal in creating Trienelle was to have a skin care product
that provided "the very best protection against skin cancer,
sun, and aging-related damage available anywhere. Period."
Although
Trienelle is priced the same as other premium skin care products,
no expense was spared in using the best materials. Dr. Ron DiSalvo,
the crËme's chief formulator, noted, "The quality of ingredients
and the high potencies of cutting-edge and active ingredients make
Trienelle probably the most expensive formula [to manufacture] that
I've ever put together."
Trienelle
should be massaged into clean skin once in the morning and once before
bedtime. Care should be taken to cover those areas most susceptible
to sun damage; the face, the back of the neck, and the ears. There's
no need to wear and additional moisturizer, as the crËme has a highly
emollient lotion base (featuring chlorella) that attracts and holds
moisture in the skin.
Aspen
Benefits Group and Trienelle skin care products are not affiliated
with the Health Sciences Institute.
For more information about the Health Sciences Institute or to become
a member, call 800-981-7157.
Trienelle's other ingredients build
a wall of protection
Melatonin heals damaged skin
Melatonin increases Trienelle's antioxidant and antiaging properties.
In fact, topically applied melatonin has been shown to protect against
sunburn and to heal skin already burned.12
Immunoprotective complex
Radiation from the sun can seriously suppress the cellular immune
system of the skin, which is the body's largest immuno-protective
organ. Skin care ingredients are now being developed and evaluated
for their IPF value (immuno-protective factor). Similar to the widely
used SPF, the IPF describes the ability of a substance to protect
against immune suppression caused by UV radiation.
Trienelle
uses reishi and versicolor mushroom extracts and HI-IG colostrums
to shield against the immuno-suppression caused by UV radiation. See
the December 1996 and January 1997 Members Alert for more information
on these powerful compounds.
Alpha-hydroxy acid (AHA) is a powerful skin exfoliant
AHA has become one of the most popular and widely used skin-care ingredients,
mostly for its ability to improve the look of mature and prematurely
aging skin through its natural exfoliating qualities.13
By
speeding the rate of turnover of dead skin cells on the surface of
the skin, AHA reduces the appearance of fine lines and wrinkles by
revealing the fresher layers beneath the surface, Trienelle includes
multi-fruit hydroxy acids (from bilberry, maple, orange, and lemon)
at a level that maximizes the therapeutic benefit and minimizes any
possible sensitivity or irritation.
Matrixyl
replenishes collagen and dissolves wrinkles
One of the chief factors in the aging of skin is the decline of collagen,
the supportive infrastructure that gives the skin its elasticity and
plumpness. Collagen naturally breaks down and degrades with age, causing
sagging, wrinkling, and the crepe-like appearance. Sun exposure, as
we've mentioned, greatly accelerates this process
Trienelle
uses Matrixyl, the state-of-the-art in collagen maintenance. This
ingredient supports and refurbishes deteriorating collagen, and is
backed up by dramatic human trials, In one double-blind placebo study,
Matrixyl was found to reduce deep wrinkles by 68 percent over six
months; moderate wrinkles were reduced by 51 percent in the same period.14
Broad-spectrum UVA/UVB sunscreen shields the skin from sun damage
Despite the dramatic new findings on antioxidant skin nutrition, many
dermatologists still hold that the most important factor in preventing
skin cancer is the consistent use of a high-quality sunscreen, Trienelle
provides everything the consumer needs in a daily skin-care regimen,
including the all-important skin-care protection (with an SPF of 15).
The sunscreen agents in Trienelle have been selected to protect against
the broadest possible range of UV radiation.
1 Skin Cancer Fact Sheet, American Academy of Dermatology, 1999
2 Free Radic Biol Med 24 (1): 55-65, 1998
3 J Bio Chem 274(22): 15345-9, 1999
4 J Eur Acad Dermatio Venereo 113(2): 96-101, 1999
5 J Am Acad Dermatol, 38(1):45-48, 1998
6 Int J Radiat Biol 75(6): 747-755, 1999
7 Nutr Cancer 29(3): 205-211, 1997
8 Free Radical Biology & Medicine, 10: 263-275, 1991
9 Clin Biochem 32(5): 309-319, 1999\
10 Lipids 33 (1): 87-91, 1998
11 Free Radic Biol Med 22 (5): 761-769, 1997
12 Archives of Dermatological Research 288(9): 552-526, 1999
13 Percept Mot Skills 86(1) : 137-138, 1998 For years, collagen itself
has been used in skin-care products to attempt to bolster a dwindling
collagen matrix.
14 "Matrixyl Tested In Vivo on a Panel of 35 Subjects During
2-4-6- Months, "Sederma, 1999
